Retrosynthesis: Carbonyl Disconnections (Aldol, Acylation, Grignard): Workflow + Practice

A retrosynthesis playbook: break complex carbonyl products into simpler pieces using classic disconnections (aldol, acyl substitution, nucleophilic…

• Reaction: Retrosynthesis: Carbonyl Disconnections (Aldol, Acylation, Grignard)
• What it does: A retrosynthesis playbook: break complex carbonyl products into simpler pieces using classic disconnections (aldol, acyl substitution, nucleophilic…
• Typical reagents: Retrosynthesis: carbonyl ← nucleophile + electrophile (e.g., organometallic + acid chloride)
• Key intermediate: Enolate
• Driving force: Formation of more stable bonds / products
• Exam type: Choose reagents
• Exam type: Plan order of operations
• Exam type: Chemoselectivity