Protecting Alcohols: THP Ethers (Acid-Labile Protection): Mechanism + Exam Traps

THP ethers protect alcohols via acetal formation using dihydropyran under acid catalysis.

• Reaction: Protecting Alcohols: THP Ethers (Acid-Labile Protection)
• What it does: THP ethers protect alcohols via acetal formation using dihydropyran under acid catalysis.
• Typical reagents: DHP, H+ (cat.)
• Key intermediate: Hemiacetal / acetal
• Driving force: Formation of more stable bonds / products
• Exam type: Choose reagents
• Exam type: Plan order of operations
• Exam type: Chemoselectivity