Protecting Alcohols: Silyl Ethers (TBS/TMS) — When and Why: Mechanism + Exam Traps
Silyl ethers protect alcohols during multi-step synthesis. Core exam ideas: how to install, relative stability, and deprotection logic (fluoride, acid).
Reaction: Protecting Alcohols: Silyl Ethers (TBS/TMS) — When and Why
What it does: Silyl ethers protect alcohols during multi-step synthesis. Core exam ideas: how to install, relative stability, and deprotection logic (fluoride, acid).
Typical reagents: TBDMSCl, imidazole
Key intermediate: Varies / context-dependent
Driving force: Formation of more stable bonds / products