Organometallic Compatibility Table (Grignard/RLi: What Kills Them?): Mechanism + Exam Traps

A canonical troubleshooting table: Grignards/RLi are strong bases and nucleophiles.

  • Reaction: Organometallic Compatibility Table (Grignard/RLi: What Kills Them?)
  • What it does: A canonical troubleshooting table: Grignards/RLi are strong bases and nucleophiles.
  • Typical reagents: CH3MgBr (dry ether; incompatible with ROH/acid)
  • Key intermediate: Epoxide / oxonium
  • Driving force: Formation of more stable bonds / products
  • Exam type: Choose reagents
  • Exam type: Plan order of operations
  • Exam type: Chemoselectivity

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