Learn when to use organocuprates: softer carbon nucleophiles for conjugate (1,4) addition to α,β‑unsaturated carbonyls and for coupling reactions (overview).
Reaction: Organocuprates (Gilman Reagents): 1,4‑Addition and Soft Nucleophiles
What it does: Learn when to use organocuprates: softer carbon nucleophiles for conjugate (1,4) addition to α,β‑unsaturated carbonyls and for coupling reactions (overview).
Typical reagents: (CH3)2CuLi then H3O+
Key intermediate: Enolate
Driving force: Formation of more stable bonds / products