Nitriles: Hydrolysis to Acids and Reduction to Amines: Mechanism + Exam Traps

Transform nitriles: hydrolyze to carboxylic acids (acid or base, heat) or reduce to primary amines (LAH or hydrogenation).

  • Reaction: Nitriles: Hydrolysis to Acids and Reduction to Amines
  • What it does: Transform nitriles: hydrolyze to carboxylic acids (acid or base, heat) or reduce to primary amines (LAH or hydrogenation).
  • Typical reagents: Compare: (1) H3O+, Δ (hydrolysis) vs (2) LiAlH4 (reduction)
  • Key intermediate: Varies / context-dependent
  • Driving force: Formation of strong C=O / oxidation state stabilization
  • Exam type: Predict major product
  • Exam type: Mechanism choice

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