Negishi Coupling: Pd-Catalyzed Cross‑Coupling with Organozinc Reagents

Learn Negishi coupling: oxidative addition, transmetalation from organozinc, reductive elimination. Why organozincs are reactive yet functional-group tolerant.

Reaction: R–X + R′–ZnX → R–R′
What it does: Cross-couples organozinc reagents with halides
Typical reagents: Pd or Ni catalyst; organozinc reagent
Key intermediate: Pd(II) or Ni(II) complexes
Driving force: Reductive elimination forms C–C bond
Exam type: Catalytic cycles
Exam type: Reagent selection

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