Lactone Formation: Intramolecular Esterification: Mechanism + Exam Traps

Form lactones from hydroxy acids via intramolecular Fischer esterification (acid-catalyzed).

  • Reaction: Lactone Formation: Intramolecular Esterification
  • What it does: Form lactones from hydroxy acids via intramolecular Fischer esterification (acid-catalyzed).
  • Typical reagents: H+, heat, remove water
  • Key intermediate: Tetrahedral intermediate
  • Driving force: Formation of more stable bonds / products
  • Exam type: Predict major product
  • Exam type: Mechanism choice

Related Resources

All 194 Mechanisms — Carbonyl Chemistry (Orgo II Core) Mechanism Flashcards AI Reaction Predictor Ask the AI Tutor