Fischer Indole Synthesis (Mechanism + Regiochemistry): Workflow + Practice

Aldehyde/ketone + phenylhydrazine → indole under acid catalysis via hydrazone formation, rearrangement, and ring closure.

• Reaction: Fischer Indole Synthesis (Mechanism + Regiochemistry)
• What it does: Aldehyde/ketone + phenylhydrazine → indole under acid catalysis via hydrazone formation, rearrangement, and ring closure.
• Typical reagents: H+ (cat.), heat
• Key intermediate: Varies / context-dependent
• Driving force: Aromaticity regained
• Exam type: Predict product
• Exam type: Rearrangement logic
• Exam type: Driving force