Grignards with Esters: Why Two Additions Occur: Mechanism + Exam Traps
Understand why Grignards add twice to esters (and acid chlorides): first addition gives a ketone intermediate that is even more reactive, leading to a tertiary…
Reaction: Grignards with Esters: Why Two Additions Occur
What it does: Understand why Grignards add twice to esters (and acid chlorides): first addition gives a ketone intermediate that is even more reactive, leading to a tertiary…
Typical reagents: 1) 2 eq CH3MgBr 2) H3O+
Key intermediate: Acyl intermediate
Driving force: Formation of strong C=O / oxidation state stabilization