Open epoxides with Grignards/RLi under basic conditions: attack the less substituted carbon (SN2), invert stereochemistry, then protonate to alcohol.
Reaction: Epoxide Opening with Organometallics (Grignard / RLi)
What it does: Open epoxides with Grignards/RLi under basic conditions: attack the less substituted carbon (SN2), invert stereochemistry, then protonate to alcohol.
Typical reagents: 1) CH3MgBr 2) H3O+
Key intermediate: Epoxide / oxonium
Driving force: Formation of strong C=O / oxidation state stabilization