Dess–Martin Periodinane (DMP): Ultra‑Mild Alcohol Oxidation (Mechanism + Uses)

Master Dess–Martin oxidation (DMP). Hypervalent iodine mechanism, why it's mild, and how it compares to PCC and Swern.

  • Reaction: ROH → aldehyde/ketone
  • What it does: Mild oxidation compatible with many functional groups
  • Typical reagents: Dess–Martin periodinane (DMP), CH2Cl2
  • Key intermediate: Alkoxyiodinane intermediate
  • Driving force: Elimination to carbonyl + reduced iodine species
  • Exam type: Reagent selection
  • Exam type: Predict product

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