Aromatic Substitution Planning (Directing Groups + Blocking Strategies): Workflow + Practice

A synthesis-oriented guide to planning EAS sequences: choose the order of substitutions using directing group logic, activation/deactivation, and blocking…

  • Reaction: Aromatic Substitution Planning (Directing Groups + Blocking Strategies)
  • What it does: A synthesis-oriented guide to planning EAS sequences: choose the order of substitutions using directing group logic, activation/deactivation, and blocking…
  • Typical reagents: Example plan: 1) Br2/FeBr3 2) HNO3/H2SO4 (order matters)
  • Key intermediate: Varies / context-dependent
  • Driving force: Formation of more stable bonds / products
  • Exam type: Choose reagents
  • Exam type: Plan order of operations
  • Exam type: Chemoselectivity

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