Anti‑Dihydroxylation via Epoxidation + Ring Opening: Mechanism + Exam Traps
Make trans (anti) diols from alkenes using epoxidation then epoxide opening. Learn regioselectivity rules (acid vs base) and stereo outcomes.
Reaction: Anti‑Dihydroxylation via Epoxidation + Ring Opening
What it does: Make trans (anti) diols from alkenes using epoxidation then epoxide opening. Learn regioselectivity rules (acid vs base) and stereo outcomes.
Typical reagents: 1) mCPBA 2) H3O+ (aq)
Key intermediate: Epoxide / oxonium
Driving force: Formation of more stable bonds / products