Amide Formation from Acid Chlorides: Mechanism + Exam Traps

Make amides efficiently by reacting acid chlorides with amines (often with base to neutralize HCl).

• Reaction: Amide Formation from Acid Chlorides
• What it does: Make amides efficiently by reacting acid chlorides with amines (often with base to neutralize HCl).
• Typical reagents: CH3NH2 (excess) or with base (Et3N)
• Key intermediate: Tetrahedral intermediate
• Driving force: Formation of more stable bonds / products
• Exam type: Predict major product
• Exam type: Mechanism choice