Acetal Formation: Protecting Aldehydes and Ketones: Mechanism + Exam Traps
Protect carbonyls as acetals/ketals using alcohol + acid (remove water). Deprotect with aqueous acid. Know why acetals survive base and many nucleophiles.
Reaction: Acetal Formation: Protecting Aldehydes and Ketones
What it does: Protect carbonyls as acetals/ketals using alcohol + acid (remove water). Deprotect with aqueous acid. Know why acetals survive base and many nucleophiles.
Typical reagents: HOCH2CH2OH, H+ (cat.), remove water
Key intermediate: Hemiacetal / acetal
Driving force: Formation of more stable bonds / products